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      1. ׬ǮĿ

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        Targeted Libraries

        The libraries contain in-stock compounds with pSEA1 value greater than 50. All libraries are available as a full or a cherry-picked set. We supply the compounds as solids, DMSO solutions, or dry films in vials or 96, 384 well plates.
        List of proteins (sorted by the human gene names):

        ACE Angiotensin-converting enzyme sdf
        ACE2 Angiotensin-converting enzyme 2 sdf
        ACKR3 Atypical chemokine receptor 3 sdf
        ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) sdf
        AGTR2 Angiotensin II type-2 receptor sdf
        AKR1C3 Aldo-keto reductase family 1 member C3 sdf
        BRCA1 Breast cancer type 1 susceptibility protein sdf
        CAPN1 Calcium-activated neutral proteinase 1 sdf
        CASP3 Caspase-3 sdf
        CASP7 Caspase-7 sdf
        CCR2 C-C chemokine receptor type 2 (C-C CKR-2) sdf
        CCR3 C-C chemokine receptor type 3 (C-C CKR-3) sdf
        CCR5 C-C chemokine receptor type 5 (C-C CKR-5) sdf
        CCR8 C-C chemokine receptor type 8 (C-C CKR-8) sdf
        CFTR Cystic fibrosis transmembrane conductance regulator sdf
        CHRNA10 Neuronal acetylcholine receptor subunit alpha-10 sdf
        CPA1 Carboxypeptidase A1 sdf
        CPT1A Carnitine palmitoyltransferase 1A sdf
        CPT2 Carnitine palmitoyltransferase I sdf
        CTSA Cathepsin A sdf
        DPP7 Dipeptidyl peptidase 7 sdf
        ECE1 Endothelin-converting enzyme 1 sdf
        ELANE Elastase-2 sdf
        ETHR Thyroid hormone receptor beta sdf
        FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A sdf
        FPR1 N-formyl peptide receptor sdf
        HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 sdf
        HTR1A 5-hydroxytryptamine receptor 1A sdf
        INHA Inhibin alpha chain sdf
        ITGA4 Integrin alpha-4 sdf
        KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 sdf
        LGMN Legumain sdf
        LIPG Endothelial lipase sdf
        MBTPS1 Membrane-bound transcription factor site-1 protease sdf
        MLNR Motilin receptor G-protein coupled receptor 38) sdf
        MME Neprilysin sdf
        NOS2 Nanos homolog 2 (NOS-2) sdf
        OPRD1 Delta-type opioid receptor (D-OR-1) (DOR-1) sdf
        P2RX7 P2X purinoceptor 7 (P2X7) sdf
        PREP Prolyl endopeptidase sdf
        RBP4 Retinol-binding protein 4 sdf
        SFRP1 Secreted frizzled-related protein 1 sdf
        SIGMAR1 Sigma non-opioid intracellular receptor 1 sdf
        SLC6A1 Sodium- and chloride-dependent GABA transporter 1 sdf
        ST14 Suppressor of tumorigenicity 14 protein sdf
        TIMP3 Tissue inhibitor of metalloproteinases 3 sdf
        TMPRSS11D Transmembrane protease serine 11D sdf
        TRPC6 Short transient receptor potential channel 6 sdf
        WNT3 Proto-oncogene Wnt-3 sdf
        XIAP E3 ubiquitin-protein ligase XIAP sdf
        1. Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nat Biotech 25 (2), 197-206 (2007)

        The following focused and targeted libraries are available upon request:

        Anti-cancer covalent kinase-oriented set
        Anti-cancer kinase library
        Appoptotic library
        Aquaporins targeted library
        Caspase focused library
        Frequent hitters library (PAINS)
        Immuno-oncology
        Ion channel modulators
        Matrix metalloproteinases targeted library
        PDE10 + PDE5/3 targeted library
        PPI targeted library
        Protease inhibitors library
        REDOX library
        Signaling pathways targeted library

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